Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169029 | 0.88 | CYP2A6 (0.44) | MAPTRAB9AALDH1A1SMN1; SMN2IDO1 | |
| SCHEMBL28264276 | 0.76 | ADORA1 (0.41) | MAPTRAB9AALDH1A1SMN1; SMN2LOXL2 | |
| SCHEMBL8591593 | 0.72 | MAPT (0.36) | MAPTLOXL2HRH4PKMMEN1 | |
| SCHEMBL21026854 | 0.72 | MTNR1A (0.44) | MAPTALDH1A1IDO1LOXL2HRH4 | |
| SCHEMBL6598876 | 0.72 | MAPT (0.51) | MAPTRAB9AALDH1A1SMN1; SMN2HRH4 | |
| SCHEMBL27785513 | 0.72 | MAPT (0.40) | MAPTRAB9AALDH1A1SMN1; SMN2LOXL2 | |
| SCHEMBL13544012 | 0.72 | RAD52 (0.41) | MAPTRAB9AALDH1A1SMN1; SMN2LOXL2 | |
| SCHEMBL19329646 | 0.72 | MAPT (0.41) | MAPTRAB9AALDH1A1SMN1; SMN2LOXL2 | |
| SCHEMBL61924 | 0.70 | GFER (0.70) | MAPTALDH1A1SMN1; SMN2LOXL2HRH4 | |
| SCHEMBL28787309 | 0.69 | MTNR1A (0.36) | MAPTRAB9AALDH1A1SMN1; SMN2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495016-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE | Astex Technology Limited (GB) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087087-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF P38 MAP KINASE | ASTEX TECHNOLOGY LIMITED (GB) | 2003-10-23 | — | — | WO | disclosed |