Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941924 | 0.92 | MKNK1 (0.40) | RENFFAR1FFAR4MKNK1CHRM5 | |
| SCHEMBL5942248 | 0.92 | CHRM5 (0.39) | MKNK1CHRM5CHRM1PTGER4CHRM2 | |
| SCHEMBL5942308 | 0.84 | CHRM5 (0.42) | RENCHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL5941620 | 0.84 | MKNK1 (0.41) | MKNK1CHRM5CHRM1PTGER4CHRM2 | |
| SCHEMBL5276073 | 0.81 | REN (0.38) | RENCHRM5CHRM1PTGER4CHRM2 | |
| SCHEMBL952114 | 0.80 | ESR2 (0.45) | MKNK1CHRM5CHRM1PTGER4HDAC1 | |
| SCHEMBL3096155 | 0.79 | CHRM5 (0.39) | CHRM5CHRM1PTGER4CHRM2CHRM4 | |
| SCHEMBL5942202 | 0.77 | CHRM5 (0.38) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL5941865 | 0.77 | CHRM5 (0.43) | RENCHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL5941836 | 0.76 | FFAR4 (0.46) | RENFFAR1FFAR4SCDSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519920-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2005-04-06 | — | — | EP | disclosed |
| WO-2004105738-A2 | USE OF TETRAHYDROPYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004002957-A1 | NOVEL TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-01-08 | — | — | WO | disclosed |