Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705746 | 0.94 | PDE4B (0.72) | PDE4BSMN1; SMN2HTR1AADRA1DADRA1A | |
| SCHEMBL4705598 | 0.94 | PDE4B (0.72) | PDE4BSMN1; SMN2HTR1AADRA1DADRA1A | |
| SCHEMBL4706954 | 0.86 | PDE4B (0.58) | PDE4BHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4058811 | 0.86 | PDE4B (0.70) | PDE4BSMN1; SMN2HTR1AADRA1DADRA1A | |
| SCHEMBL4706107 | 0.86 | PDE4B (0.70) | PDE4BSMN1; SMN2HTR1AADRA1DADRA1A | |
| SCHEMBL4707463 | 0.86 | PDE4B (0.72) | PDE4BSMN1; SMN2HTR1AADRA1DADRA1A | |
| SCHEMBL4707352 | 0.86 | PDE4B (0.69) | PDE4BSMN1; SMN2HTR1AADRA1DADRA1A | |
| SCHEMBL4707416 | 0.85 | PDE4B (0.80) | PDE4BSMN1; SMN2HTR1AADRA1DADRA1A | |
| SCHEMBL4708776 | 0.85 | PDE4B (0.80) | PDE4BSMN1; SMN2HTR1AADRA1DADRA1A | |
| SCHEMBL4706104 | 0.85 | PDE4B (0.68) | PDE4BSMN1; SMN2HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |