Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.74 |
| ▸ | MME | P08473 | 7/20 | 0.69 |
| ▸ | CPA1 | P15085 | 3/20 | 0.59 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169325 | 1.00 | ACE (0.74) | ACEMMECPA1ACE2 | |
| SCHEMBL6168678 | 0.91 | MME (0.82) | ACEMMECPA1ACE2 | |
| SCHEMBL6171524 | 0.91 | MME (0.82) | ACEMMECPA1ACE2 | |
| SCHEMBL6173142 | 0.85 | MME (0.86) | MME | |
| SCHEMBL6173139 | 0.85 | MME (0.86) | MME | |
| SCHEMBL6171516 | 0.85 | ACE (0.60) | ACEMMECPA1ACE2 | |
| SCHEMBL6171518 | 0.85 | ACE (0.60) | ACEMMECPA1ACE2 | |
| SCHEMBL7441105 | 0.85 | ACE (1.00) | ACE | |
| SCHEMBL7445462 | 0.84 | MME (0.76) | ACEMMECPA1ACE2 | |
| SCHEMBL6159992 | 0.82 | MME (0.69) | ACEMMECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888341-B1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | AVENTIS PHARMA SA (FR) | 2005-11-30 | — | — | EP | disclosed |
| US-6136842-A | INHIBITION OF ENDOTHELIN-CONVERTING ENZYME | HOECHST MARION ROUSSEL (FR) | 2000-10-24 | — | — | US | disclosed |