Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
| ▸ | LIPE | Q05469 | 5/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175979 | 0.91 | LMNA (0.37) | LMNAHRH4POLBL3MBTL1GPR139 | |
| SCHEMBL6173184 | 0.91 | LMNA (0.36) | LMNAHRH4POLBL3MBTL1GPR139 | |
| SCHEMBL6176133 | 0.89 | LMNA (0.41) | LMNAPOLBGPR139 | |
| SCHEMBL6172084 | 0.89 | LMNA (0.40) | LMNAIGF1RHRH4POLBL3MBTL1 | |
| SCHEMBL6173153 | 0.88 | LMNA (0.41) | LMNAABL1BCRPOLBL3MBTL1 | |
| SCHEMBL6173894 | 0.86 | IGF1R (0.37) | LMNAIGF1RKIF11HRH4 | |
| SCHEMBL6175038 | 0.85 | LMNA (0.38) | LMNAIGF1RGPR139LIPE | |
| SCHEMBL6173626 | 0.83 | SLC5A1 (0.37) | LMNAABL1PDE2A | |
| SCHEMBL6173438 | 0.83 | LMNA (0.42) | LMNAABL1HRH4POLBL3MBTL1 | |
| SCHEMBL6175578 | 0.83 | LMNA (0.42) | LMNAHRH4POLBL3MBTL1GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |