Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5392736 | 0.88 | ALDH1A1 (0.51) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL6024797 | 0.88 | ALDH1A1 (0.48) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL5392742 | 0.88 | ALDH1A1 (0.51) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL6036480 | 0.88 | ALDH1A1 (0.48) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL3725269 | 0.84 | CREBBP (0.48) | MAPTALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL3725267 | 0.84 | CREBBP (0.48) | MAPTALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL6169905 | 0.81 | ALDH1A1 (0.50) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL6169288 | 0.81 | ALDH1A1 (0.50) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL6169914 | 0.81 | ALDH1A1 (0.50) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL6169292 | 0.81 | ALDH1A1 (0.50) | MAPTALDH1A1KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |