Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.45 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | USP8 | P40818 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169825 | 1.00 | GAA (0.48) | GAAMEN1KMT2ACCR1CCR2 | |
| SCHEMBL6169480 | 0.91 | KDM1A (0.48) | GAAMEN1KMT2ACCR1CCR2 | |
| SCHEMBL6169474 | 0.91 | KDM1A (0.48) | GAAMEN1KMT2ACCR1CCR2 | |
| SCHEMBL7482984 | 0.89 | MEN1 (0.52) | GAAMEN1KMT2ACCR1CCR2 | |
| SCHEMBL7482989 | 0.89 | MEN1 (0.52) | GAAMEN1KMT2ACCR1CCR2 | |
| SCHEMBL18046757 | 0.86 | GAA (0.58) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL18046760 | 0.86 | GAA (0.58) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6169289 | 0.84 | METAP2 (0.54) | GAAMEN1KMT2ACCR2ALDH1A1 | |
| SCHEMBL6169283 | 0.84 | METAP2 (0.54) | GAAMEN1KMT2ACCR2ALDH1A1 | |
| SCHEMBL6173095 | 0.83 | ERBB2 (0.52) | GAAMEN1KMT2ACCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1065206-B1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1065206-A1 | Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents | PFIZER INC. (US) | 2001-01-03 | — | — | EP | disclosed |