Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 14/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170710 | 0.91 | PTGS2 (0.53) | PTGS2PTGS1CDK2ABCB11ALDH1A1 | |
| SCHEMBL4888565 | 0.89 | PTGS2 (0.67) | PTGS2PTGS1CDK2 | |
| SCHEMBL27539938 | 0.86 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL6168516 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1CDK2ABCB11ALDH1A1 | |
| SCHEMBL6167687 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1CDK2ABCB11ALDH1A1 | |
| SCHEMBL6168801 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1CDK2 | |
| SCHEMBL6170654 | 0.86 | PTGS2 (0.55) | PTGS2PTGS1CDK2ABCB11ALDH1A1 | |
| SCHEMBL6171523 | 0.85 | PTGS2 (0.54) | PTGS2PTGS1CDK2 | |
| SCHEMBL6170018 | 0.83 | PTGS2 (0.52) | PTGS2PTGS1CDK2 | |
| SCHEMBL8478643 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1ABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5985902-A | TREATING INFLAMMATION AND INFLAMMATION-ASSOCIATED DISORDERS, SUCH AS ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | disclosed |
| US-5633272-A | Substituted isoxazoles for the treatment of inflammation | PHARMACIA & UPJOHN COMPANY LLC | 1997-05-27 | — | — | US | disclosed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | disclosed |