Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679397 | 0.85 | LMNA (0.70) | LMNACYP3A4ACHE | |
| SCHEMBL4777988 | 0.83 | LMNA (0.72) | LMNACYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL11212235 | 0.83 | TP53 (0.55) | LMNACYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL17028900 | 0.82 | LMNA (0.76) | LMNACYP3A4MEN1KMT2AACHE | |
| SCHEMBL249305 | 0.82 | LMNA (0.76) | LMNACYP3A4MEN1KMT2AACHE | |
| SCHEMBL6653396 | 0.81 | LMNA (0.59) | LMNACYP3A4MEN1KMT2AACHE | |
| SCHEMBL9787099 | 0.80 | MAPT (0.58) | LMNACYP3A4MEN1KMT2AKDM4E | |
| SCHEMBL5532773 | 0.79 | KMT2A (0.60) | LMNAMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL9692573 | 0.78 | KMT2A (0.61) | LMNACYP3A4KMT2AACHE | |
| SCHEMBL14341656 | 0.78 | LMNA (0.56) | LMNACYP3A4MEN1KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534693-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2005-06-01 | — | — | EP | claimed |
| WO-2004022523-A2 | 1, 3-DIAMINO-2-HYDROXYPROPANE PRODRUG DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2004-03-18 | — | — | WO | claimed |