Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 3/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708827 | 0.92 | PDE4B (0.51) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4706440 | 0.92 | PDE4B (0.54) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4708421 | 0.83 | PDE4B (0.65) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4707529 | 0.82 | PDE4B (0.54) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4706063 | 0.82 | PDE4B (0.54) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4706489 | 0.81 | PDE4B (0.70) | PDE4BACHEBACE1SMN1; SMN2MAPT | |
| SCHEMBL4707901 | 0.81 | PDE4B (0.65) | PDE4BKMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL6168738 | 0.80 | PDE4B (0.41) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4707247 | 0.79 | PDE4B (0.75) | PDE4BACHEBACE1PDE4APDE4C | |
| SCHEMBL4706532 | 0.78 | PDE4B (0.57) | PDE4BKMT2ASMN1; SMN2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |