Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708827 | 0.81 | PDE4B (0.51) | PDE4BPDE4AACHEBACE1RXFP1 | |
| SCHEMBL4707529 | 0.80 | PDE4B (0.54) | PDE4BPDE4AACHEBACE1PARP1 | |
| SCHEMBL4706063 | 0.80 | PDE4B (0.54) | PDE4BPDE4AACHEBACE1ABCG2 | |
| SCHEMBL6170308 | 0.80 | PDE4B (0.48) | PDE4BPDE4AACHEBACE1RXFP1 | |
| SCHEMBL6174791 | 0.78 | PDE4B (0.46) | PDE4BACHEBACE1PARP1ABCG2 | |
| SCHEMBL4708038 | 0.78 | PDE4B (0.54) | PDE4BPTGIRPDE4AACHEBACE1 | |
| SCHEMBL4708371 | 0.78 | PDE4B (0.54) | PDE4BPTGIRBRD4CREBBPMCHR1 | |
| SCHEMBL4706640 | 0.77 | PDE4B (0.50) | PDE4BPTGIRPDE4ACREBBPMERTK | |
| SCHEMBL4706986 | 0.77 | PDE4B (0.57) | PDE4BPDE4AACHEBACE1PARP1 | |
| SCHEMBL1654229 | 0.77 | PDE4B (0.52) | PDE4BACHEBACE1PARP1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |