Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171079 | 0.87 | PTGS2 (0.57) | PTGS2PTGS1KDM4EMEN1KMT2A | |
| SCHEMBL6171368 | 0.86 | PTGS2 (0.58) | PTGS2PTGS1KDM4EMEN1KMT2A | |
| SCHEMBL6170265 | 0.82 | PTGS2 (0.61) | PTGS2PTGS1KDM4EMEN1KMT2A | |
| SCHEMBL6170624 | 0.81 | PTGS2 (0.42) | PTGS2PTGS1KDM4EMEN1KMT2A | |
| SCHEMBL6169956 | 0.80 | PTGS2 (0.77) | PTGS2PTGS1KDM4EMEN1KMT2A | |
| SCHEMBL6172533 | 0.79 | MAPT (0.54) | PTGS2PTGS1KDM4EMEN1KMT2A | |
| SCHEMBL6171976 | 0.79 | PTGS2 (0.48) | PTGS2PTGS1MEN1KMT2AALDH1A1 | |
| SCHEMBL6171069 | 0.76 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL27540478 | 0.74 | PTGS2 (0.54) | PTGS2PTGS1KDM4EMEN1KMT2A | |
| SCHEMBL28744452 | 0.73 | PTGS2 (0.69) | PTGS2PTGS1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |