SCHEMBL6170757

SCHEMBL6170757

CCC(=O)C(=Cc1ccccc1)c1ccc(SC)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 5/20 0.64
AKR1C1 Q04828 4/20 0.64
AKR1C2 P52895 3/20 0.64
MAPT P10636 3/20 0.44
LMNA P02545 2/20 0.44
HTT P42858 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
KDM4E B2RXH2 1/20 0.43
NPC1 O15118 1/20 0.43
NFKB1 P19838 1/20 0.43
RAB9A P51151 1/20 0.43
NFKB2 Q00653 1/20 0.43
RELA Q04206 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6170751 1.00 AKR1C3 (0.64) AKR1C3AKR1C1AKR1C2MAPTLMNA
SCHEMBL6169402 0.86 AKR1C1 (0.63) AKR1C3AKR1C1AKR1C2MAPTLMNA
SCHEMBL6169399 0.86 AKR1C1 (0.63) AKR1C3AKR1C1AKR1C2MAPTLMNA
SCHEMBL6168025 0.83 AKR1C3 (0.69) AKR1C3AKR1C1AKR1C2MAPTLMNA
SCHEMBL6168027 0.83 AKR1C3 (0.69) AKR1C3AKR1C1AKR1C2MAPTLMNA
SCHEMBL6170534 0.80 AKR1C3 (0.54) AKR1C3AKR1C1AKR1C2MAPTLMNA
SCHEMBL6170539 0.80 AKR1C3 (0.54) AKR1C3AKR1C1AKR1C2MAPTLMNA
SCHEMBL7842239 0.78 AKR1C3 (1.00) AKR1C3AKR1C1AKR1C2MAPTLMNA
SCHEMBL7842236 0.78 AKR1C3 (1.00) AKR1C3AKR1C1AKR1C2MAPTLMNA
SCHEMBL6169895 0.77 AKR1C1 (0.79) AKR1C3AKR1C1AKR1C2MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1214790-C Medicinal composition for treating inflammation SEARLE & CO (US) 2005-08-17 CN disclosed
EP-1528059-A2 Substituted isoxazoles for the treatment of inflammation G.D. Searle LLC (US) 2005-05-04 EP disclosed
CN-1442139-A Medicinal composition for treating inflammation SEARLE & CO (US) 2003-09-17 CN disclosed
EP-0809636-B1 SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION SEARLE & CO (US) 2002-09-04 EP disclosed
EP-1223167-A2 Substituted isoxazoles for the treatment of inflammation G.D. Searle & Co. (US) 2002-07-17 EP disclosed
US-5859257-A ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS G. D. SEARLE & CO. (US) 1999-01-12 US disclosed
EP-0809636-A1 SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1997-12-03 EP disclosed
WO-1996025405-A1 SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-08-22 WO disclosed