Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169402 | 1.00 | AKR1C1 (0.63) | AKR1C1MAPTLMNAHTTNPSR1 | |
| SCHEMBL6170751 | 0.86 | AKR1C3 (0.64) | AKR1C1MAPTLMNAHTTNPSR1 | |
| SCHEMBL6170757 | 0.86 | AKR1C3 (0.64) | AKR1C1MAPTLMNAHTTNPSR1 | |
| Alcohol SCHEMBL27937505 | 0.81 | AKR1C1 (0.81) | AKR1C1MAPTLMNAHTTNPSR1 | |
| SCHEMBL11881810 | 0.81 | CES1 (0.59) | AKR1C1MAPTLMNAHTTNPSR1 | |
| SCHEMBL2037146 | 0.81 | CES1 (0.59) | AKR1C1MAPTLMNAHTTNPSR1 | |
| SCHEMBL15664806 | 0.80 | MEN1 (0.55) | AKR1C1MAPTLMNAHTTNPSR1 | |
| SCHEMBL15664807 | 0.80 | MEN1 (0.55) | AKR1C1MAPTLMNAHTTNPSR1 | |
| SCHEMBL8038875 | 0.80 | MEN1 (0.63) | AKR1C1LMNAHTTCYP2C9CYP3A4 | |
| SCHEMBL11219398 | 0.80 | AKR1C1 (0.73) | AKR1C1MAPTLMNAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58150533-A | — | — | None | — | — | JP | disclosed |
| EP-1528059-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle LLC (US) | 2005-05-04 | — | — | EP | disclosed |
| EP-0809636-B1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1223167-A2 | Substituted isoxazoles for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| JP-S58150533-A | PREPARATION OF ALPHA,BETA-UNSATURATED KETONE | RIKAGAKU KENKYUSHO | 1983-09-07 | — | — | JP | disclosed |