Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 8/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170035 | 0.88 | MEN1 (0.63) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6172428 | 0.84 | MEN1 (0.62) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6171786 | 0.82 | MEN1 (0.57) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6169053 | 0.82 | GPR183 (0.58) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6169487 | 0.82 | ALOX15 (0.58) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6170605 | 0.82 | MEN1 (0.78) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6168778 | 0.80 | ALOX15 (0.59) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6169709 | 0.79 | MEN1 (0.57) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL6171399 | 0.79 | MEN1 (0.53) | ALOX15MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4268371 | 0.79 | MAP2K1 (0.51) | ALOX15MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |