Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.61 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169641 | 0.89 | PTGS2 (0.59) | PTGS2GPR17PTGS1 | |
| SCHEMBL6171550 | 0.84 | PTGS2 (0.64) | PTGS2GPR17PTGS1 | |
| SCHEMBL6170112 | 0.82 | PTGS2 (0.59) | PTGS2GPR17 | |
| SCHEMBL6168380 | 0.81 | PTGS2 (0.70) | PTGS2GPR17PTGS1 | |
| SCHEMBL6171284 | 0.81 | PTGS2 (0.70) | PTGS2GPR17PTGS1 | |
| SCHEMBL6169311 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL6172566 | 0.81 | PTGS2 (0.58) | PTGS2GPR17 | |
| SCHEMBL6169769 | 0.81 | PTGS2 (0.59) | PTGS2GPR17 | |
| SCHEMBL6168744 | 0.80 | PTGS2 (0.59) | PTGS2GPR17PTGS1 | |
| SCHEMBL6170649 | 0.80 | PTGS2 (0.51) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | claimed |