Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26917090 | 0.88 | DGAT1 (0.35) | DGAT1MAPTNPC1KLKB1 | |
| SCHEMBL3973414 | 0.85 | SMN1; SMN2 (0.35) | DGAT1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7082758 | 0.85 | DGAT1 (0.34) | DGAT1MAPTNPC1KLKB1 | |
| SCHEMBL3405493 | 0.84 | DGAT1 (0.37) | DGAT1MAPTNPC1 | |
| SCHEMBL3313603 | 0.83 | NPC1 (0.40) | DGAT1MAPTNPC1KLKB1 | |
| SCHEMBL8664242 | 0.83 | DGAT1 (0.34) | DGAT1MAPTNPC1KLKB1 | |
| SCHEMBL5661987 | 0.82 | DGAT1 (0.36) | DGAT1MAPTNPC1SMN1; SMN2 | |
| SCHEMBL5973964 | 0.81 | DGAT1 (0.40) | DGAT1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31305763 | 0.81 | SMN1; SMN2 (0.33) | DGAT1MAPTNPC1SMN1; SMN2KLKB1 | |
| SCHEMBL22645106 | 0.80 | DGAT1 (0.39) | DGAT1MAPTNPC1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| CN-1284064-A | 2,3-substituted indole compounds as cox-2 inhibitors | PFIZER PHARMA (US) | 2001-02-14 | — | — | CN | disclosed |