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SCHEMBL6172277

SCHEMBL6172277

CC(c1ccnc(NC(=O)Oc2ccccc2)c1)C1(C(C)c2ccnc(NC(=O)Oc3ccccc3)c2)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.45

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 16/20 0.45
▸ PDE2A O00408 3/20 0.38
▸ MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6177118 0.91 IGF1R (0.49) IGF1RPDE2A
SCHEMBL6176861 0.89 PDE2A (0.39) PDE2AMAPK1
SCHEMBL6174504 0.89 IGF1R (0.48) IGF1RPDE2A
SCHEMBL17558370 0.88 IGF1R (0.58) IGF1RPDE2A
SCHEMBL6173078 0.87 IGF1R (0.45) IGF1RPDE2AMAPK1
SCHEMBL17558385 0.87 IGF1R (0.56) IGF1R
SCHEMBL6172324 0.86 IGF1R (0.47) IGF1R
SCHEMBL6174011 0.84 IGF1R (0.56) IGF1R
SCHEMBL6171207 0.84 IGF1R (0.44) IGF1R
SCHEMBL6174715 0.84 CYP3A4 (0.45) IGF1RPDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed