Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171779 | 0.92 | IGF1R (0.40) | IGF1RARKMT2ALMNASLC22A12 | |
| SCHEMBL6175293 | 0.92 | IGF1R (0.45) | IGF1RTP53ARKMT2ATSHR | |
| SCHEMBL6175003 | 0.91 | CYP3A4 (0.43) | IGF1RARSLC22A12ALDH1A1PTGS2 | |
| SCHEMBL6172113 | 0.85 | IGF1R (0.40) | IGF1RARKMT2AHTTALDH1A1 | |
| SCHEMBL6173328 | 0.85 | IGF1R (0.44) | IGF1RTP53ARKMT2ALMNA | |
| SCHEMBL6175170 | 0.85 | IGF1R (0.44) | IGF1RTP53ARKMT2ALMNA | |
| SCHEMBL6175255 | 0.85 | IGF1R (0.44) | IGF1RTP53ARKMT2ALMNA | |
| SCHEMBL6174749 | 0.85 | AR (0.38) | ARKMT2ATSHRLMNAHTT | |
| SCHEMBL6171903 | 0.84 | IGF1R (0.45) | IGF1RTP53ARKMT2ATSHR | |
| SCHEMBL6169737 | 0.84 | IGF1R (0.43) | IGF1RARKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |