Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171779 | 0.90 | IGF1R (0.40) | IGF1RITGALARMAPTTHRB | |
| SCHEMBL6175293 | 0.90 | IGF1R (0.45) | IGF1RALDH1A1KDM4ESMN1; SMN2AR | |
| SCHEMBL6173726 | 0.86 | IGF1R (0.42) | IGF1RITGALALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6170776 | 0.86 | DGAT2 (0.38) | ITGALALDH1A1KDM4ESMN1; SMN2AR | |
| SCHEMBL6169737 | 0.86 | IGF1R (0.43) | IGF1RITGALALDH1A1ARPTGS2 | |
| SCHEMBL6172334 | 0.85 | IGF1R (0.40) | IGF1RALDH1A1ARPTGS2PTGS1 | |
| SCHEMBL6171403 | 0.84 | IGF1R (0.43) | IGF1RITGALALDH1A1ARMAPT | |
| SCHEMBL6175003 | 0.83 | CYP3A4 (0.43) | IGF1RALDH1A1ARPTGS2MAPT | |
| SCHEMBL6171903 | 0.82 | IGF1R (0.45) | IGF1RALDH1A1ARPTGS2PTGS1 | |
| SCHEMBL6172432 | 0.82 | ALDH1A1 (0.38) | IGF1RALDH1A1SMN1; SMN2MAPTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |