Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | AR | P10275 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173676 | 0.91 | IGF1R (0.52) | IGF1RARKMT2ATP53TSHR | |
| SCHEMBL6172915 | 0.90 | IGF1R (0.51) | IGF1RARKMT2ATP53SMN1; SMN2 | |
| SCHEMBL6173567 | 0.90 | IGF1R (0.51) | IGF1RARKMT2ATP53THRB | |
| SCHEMBL6169082 | 0.89 | IGF1R (0.50) | IGF1RARKMT2ATP53TSHR | |
| SCHEMBL6171503 | 0.87 | IGF1R (0.65) | IGF1RARKMT2ATP53SMN1; SMN2 | |
| SCHEMBL6175292 | 0.87 | IGF1R (0.65) | IGF1RARKMT2ATP53SMN1; SMN2 | |
| SCHEMBL6175236 | 0.86 | IGF1R (0.50) | IGF1RARKMT2ATP53EGLN1 | |
| Trifluoroacetic Acid SCHEMBL17558350 | 0.83 | IGF1R (0.60) | IGF1RARKMT2ASMN1; SMN2ITGAL | |
| Trifluoroacetic Acid SCHEMBL17558459 | 0.83 | IGF1R (0.60) | IGF1RARKMT2ASMN1; SMN2ITGAL | |
| SCHEMBL6174186 | 0.83 | IGF1R (0.51) | IGF1RARKMT2ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |