Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.60 |
| ▸ | AR | P10275 | 3/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL17558350 | 1.00 | IGF1R (0.60) | IGF1RARPTGDR2NAMPTLMNA | |
| SCHEMBL6171503 | 0.95 | IGF1R (0.65) | IGF1RARPTGDR2NAMPTHSD11B1 | |
| SCHEMBL6175292 | 0.95 | IGF1R (0.65) | IGF1RARPTGDR2NAMPTHSD11B1 | |
| Trifluoroacetic Acid SCHEMBL17558379 | 0.85 | IGF1R (0.42) | IGF1RAR | |
| SCHEMBL6250335 | 0.84 | IGF1R (0.51) | IGF1RARLMNAKMT2ACYP1A2 | |
| Trifluoroacetic Acid SCHEMBL17558458 | 0.84 | IGF1R (0.52) | IGF1RARPTGDR2NAMPTLMNA | |
| SCHEMBL6174186 | 0.84 | IGF1R (0.51) | IGF1RARLMNAKMT2ACYP1A2 | |
| Trifluoroacetic Acid SCHEMBL17558384 | 0.83 | IGF1R (0.51) | IGF1RARPTGDR2NAMPTMMP13 | |
| SCHEMBL6173676 | 0.83 | IGF1R (0.52) | IGF1RARKMT2AITGAL | |
| SCHEMBL6172368 | 0.83 | IGF1R (0.52) | IGF1RARKMT2ASMN1; SMN2ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188729-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | Genzyme Corporation (US) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016036796-A1 | CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS | GENZYME CORPORATION (US) | 2016-03-10 | — | — | WO | disclosed |