Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172674 | 1.00 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7419473 | 0.91 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8355323 | 0.89 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7333259 | 0.89 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7363476 | 0.89 | PDE4B (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7371833 | 0.89 | PDE4B (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7356387 | 0.88 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7356382 | 0.88 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8357451 | 0.87 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8357454 | 0.87 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794774-B1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-12 | — | — | EP | claimed |
| WO-1996019988-A1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-04 | — | — | WO | claimed |
| EP-0794774-B1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-12 | — | — | EP | disclosed |
| EP-1051172-B1 | METHOD FOR TREATING COPD | SMITHKLINE BEECHAM CORP (US) | 2004-12-22 | — | — | EP | disclosed |
| US-6369108-B1 | CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | disclosed |
| US-5977122-A | 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| US-5891883-A | 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1996019988-A1 | 4,4-(DISUBSTITUTED)CYCLOHEXAN-1-OLS MONOMERS AND RELATED COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-04 | — | — | WO | disclosed |