SCHEMBL6172734

SCHEMBL6172734

Cc1nc(-c2ccc(F)cc2)c(-c2ccc(F)cc2)n1CCCCCCNC(=O)Oc1ccccc1F.Cc1nc(-c2ccccc2)c(-c2ccccc2)n1CCCCCCNC(=O)Oc1ccc(F)c(F)c1

nearest known ligand 0.83

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FAAH O00519 13/20 0.83
CNR1 P21554 1/20 0.81
CNR2 P34972 1/20 0.81
PLA2G4A P47712 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4552448 0.93 FAAH (0.79) FAAHCNR1CNR2PLA2G4A
SCHEMBL5374409 0.91 FAAH (1.00) FAAHCNR1CNR2PLA2G4A
SCHEMBL4562549 0.90 FAAH (1.00) FAAHCNR1CNR2PLA2G4A
SCHEMBL4263058 0.90 FAAH (1.00) FAAHCNR1CNR2PLA2G4A
SCHEMBL29646274 0.90 FAAH (1.00) FAAHCNR1CNR2PLA2G4A
SCHEMBL1709522 0.90 FAAH (1.00) FAAHCNR1CNR2PLA2G4A
SCHEMBL4551680 0.88 FAAH (0.87) FAAHCNR1CNR2PLA2G4A
SCHEMBL4267650 0.88 FAAH (0.87) FAAHCNR1CNR2PLA2G4A
SCHEMBL4265722 0.88 FAAH (0.87) FAAHCNR1CNR2PLA2G4A
SCHEMBL4265721 0.87 FAAH (0.86) FAAHCNR1CNR2PLA2G4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1389107-A4 BISARYLIMIDAZOLYL FATTY ACID AMIDE HYDROLASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2005-10-12 EP claimed
EP-1389107-A1 BISARYLIMIDAZOLYL FATTY ACID AMIDE HYDROLASE INHIBITORS Bristol-Myers Squibb Company (US) 2004-02-18 EP claimed
WO-2002087569-A1 BISARYLIMIDAZOLYL FATTY ACID AMIDE HYDROLASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2002-11-07 WO claimed