Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.59 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | GALR3 | O60755 | 2/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | PDE6D | O43924 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170123 | 0.88 | TNF (0.58) | SPHK1TNFGALR3NR2F2RAB9A | |
| SCHEMBL6170384 | 0.84 | HDAC1 (0.57) | SPHK1TNFGALR3NR2F2RAB9A | |
| SCHEMBL6171309 | 0.82 | GALR3 (0.51) | SPHK1TNFGALR3NR2F2RAB9A | |
| SCHEMBL9260111 | 0.80 | TNF (0.77) | TNFGALR3NR2F2RAB9AHDAC1 | |
| SCHEMBL6168941 | 0.79 | PDE2A (0.56) | SPHK1TNFRAB9AHDAC1HDAC6 | |
| SCHEMBL6172378 | 0.77 | TRPC5 (0.47) | SPHK1TNFGALR3NR2F2RAB9A | |
| SCHEMBL3100051 | 0.77 | TNF (0.70) | TNFGALR3NR2F2RAB9AHDAC1 | |
| SCHEMBL15071579 | 0.76 | TNF (0.69) | TNFGALR3NR2F2RAB9AHDAC1 | |
| SCHEMBL615476 | 0.75 | TNF (0.68) | SPHK1TNFGALR3NR2F2RAB9A | |
| SCHEMBL1160341 | 0.75 | HDAC1 (0.55) | SPHK1HDAC1HDAC6ALDH1A1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882718-B1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2005-08-31 | — | — | EP | disclosed |
| US-6369092-B1 | Method for treating neoplasia by exposure to substituted benzimidazole derivatives | CELL PATHWAYS, INC. | 2002-04-09 | — | — | US | disclosed |
| US-6352985-B1 | CARDIOVASCULAR DISORDERS OR GASTROINTESTINAL DISORDERS, DIABETES (TYPE II DIABETES), DIABETIC COMPLICATIONS METHOD FOR LOWERING THE BLOOD SUGAR LEVEL OF A PATIENT, | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| US-6166219-A | Benzimidazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0882718-A1 | BENZIMIDAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |