Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 2/20 | 0.42 |
| ▸ | PLD2 | O14939 | 1/20 | 0.41 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171399 | 0.92 | MEN1 (0.53) | MEN1NPC1RAB9AKMT2AP2RY14 | |
| SCHEMBL27904158 | 0.85 | FLT3 (0.53) | P2RY14PDGFRBFLT3GPR183 | |
| SCHEMBL6170035 | 0.84 | MEN1 (0.63) | MEN1NPC1RAB9AKMT2AALOX15 | |
| SCHEMBL6171501 | 0.83 | MEN1 (0.53) | MEN1NPC1RAB9AKMT2AALOX15 | |
| SCHEMBL30067540 | 0.80 | HRH4 (0.45) | P2RY14ALOX15GPR183PLD2PLD1 | |
| SCHEMBL6169053 | 0.79 | GPR183 (0.58) | MEN1NPC1RAB9AKMT2AALOX15 | |
| SCHEMBL3643672 | 0.78 | HPGD (0.54) | MEN1KMT2AP2RY14MAPT | |
| SCHEMBL29619366 | 0.77 | P2RY14 (0.50) | P2RY14GPR183PLD2PLD1 | |
| SCHEMBL6168456 | 0.77 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL6171786 | 0.76 | MEN1 (0.57) | MEN1NPC1RAB9AKMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |