Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 2/20 | 0.50 |
| ▸ | KIF11 | P52732 | 5/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | PLD2 | O14939 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30314640 | 0.87 | HRH4 (0.58) | P2RY14KIF11HRH4MAP2K4PLD2 | |
| SCHEMBL27904158 | 0.87 | FLT3 (0.53) | P2RY14HRH4METAP2GPR183MPL | |
| SCHEMBL3643672 | 0.85 | HPGD (0.54) | P2RY14HRH4METAP2MPL | |
| SCHEMBL30067540 | 0.84 | HRH4 (0.45) | P2RY14KIF11HRH4METAP2GPR183 | |
| SCHEMBL13552126 | 0.84 | SCN10A (0.48) | KIF11SCN10APLGPLAU | |
| SCHEMBL717595 | 0.80 | KIF11 (0.44) | P2RY14KIF11HRH4PARP1MPL | |
| SCHEMBL926647 | 0.80 | CFTR (0.49) | P2RY14KIF11HRH4PLD2PLD1 | |
| SCHEMBL34471210 | 0.80 | CFTR (0.49) | P2RY14KIF11HRH4PLD2PLD1 | |
| SCHEMBL16795602 | 0.80 | P2RY14 (0.42) | P2RY14HRH4METAP2SCN10AGPR183 | |
| SCHEMBL28858007 | 0.79 | P2RY14 (0.49) | P2RY14KIF11HRH4PARP1MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232447-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | Evotec International GmbH (DE) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022084447-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2022-04-28 | — | — | WO | disclosed |