Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.36 |
| ▸ | ELOVL3 | Q9HB03 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933782 | 0.83 | IGF1R (0.60) | RAF1LCKRETCYP3A4KIT | |
| SCHEMBL2939459 | 0.77 | IGF1R (0.60) | RAF1LCKRETCYP3A4KIT | |
| SCHEMBL2936903 | 0.76 | IGF1R (0.72) | RAF1LCKRETCYP3A4KIT | |
| SCHEMBL13039192 | 0.76 | IGF1R (0.58) | RAF1LCKRETCYP3A4KIT | |
| Trifluoroacetic Acid SCHEMBL2933028 | 0.72 | IGF1R (0.65) | RAF1LCKRETCYP3A4KIT | |
| SCHEMBL2938311 | 0.72 | IGF1R (0.55) | RAF1LCKRETCYP3A4KIT | |
| SCHEMBL2933031 | 0.70 | RAF1 (0.40) | RAF1LCKRETCYP3A4KIT | |
| SCHEMBL6170677 | 0.69 | IGF1R (0.48) | IGF1RARKCNH2TRPV1 | |
| SCHEMBL6175751 | 0.68 | AR (0.41) | RAF1LCKRETCYP3A4KIT | |
| Trifluoroacetic Acid SCHEMBL2941717 | 0.68 | IGF1R (0.51) | RAF1LCKRETCYP3A4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |