Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173314 | 1.00 | BACE1 (0.66) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL708120 | 0.89 | ALDH1A1 (0.61) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL708119 | 0.89 | ALDH1A1 (0.61) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3578531 | 0.89 | ALDH1A1 (0.61) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6172741 | 0.87 | BACE1 (0.68) | BACE1MAPTALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL15652345 | 0.87 | ALDH1A1 (0.60) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6172745 | 0.87 | BACE1 (0.68) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL19284517 | 0.81 | ALDH1A1 (0.57) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL19284518 | 0.81 | ALDH1A1 (0.57) | BACE1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL27560484 | 0.81 | CYP19A1 (0.66) | BACE1MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1065204-B1 | Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents and as COX-2 inhibitors | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |