Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172754 | 0.89 | IGF1R (0.41) | IGF1RKDM4ELMNA | |
| SCHEMBL6174748 | 0.88 | IGF1R (0.43) | IGF1R | |
| SCHEMBL6174986 | 0.87 | IGF1R (0.42) | IGF1R | |
| SCHEMBL6175884 | 0.85 | IGF1R (0.41) | IGF1RLMNA | |
| SCHEMBL6173973 | 0.84 | IGF1R (0.46) | IGF1R | |
| SCHEMBL6173796 | 0.84 | IGF1R (0.52) | IGF1R | |
| SCHEMBL6174760 | 0.83 | IGF1R (0.41) | IGF1R | |
| SCHEMBL6174194 | 0.83 | IGF1R (0.42) | IGF1RLMNA | |
| SCHEMBL6177584 | 0.82 | IGF1R (0.38) | IGF1RLMNA | |
| SCHEMBL6174695 | 0.81 | LMNA (0.39) | IGF1RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |