Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175657 | 0.88 | IGF1R (0.45) | IGF1RITGALARPOLBL3MBTL1 | |
| SCHEMBL6176754 | 0.88 | ITGAL (0.44) | IGF1RITGALARPOLBL3MBTL1 | |
| SCHEMBL6172079 | 0.86 | IGF1R (0.47) | IGF1RITGALARPOLBL3MBTL1 | |
| SCHEMBL6175573 | 0.86 | ITGAL (0.39) | IGF1RITGALARPOLBL3MBTL1 | |
| SCHEMBL6171047 | 0.86 | IGF1R (0.48) | IGF1RITGALARPOLBL3MBTL1 | |
| SCHEMBL6171575 | 0.86 | IGF1R (0.40) | IGF1RITGALARPOLBL3MBTL1 | |
| SCHEMBL6175755 | 0.85 | ITGAL (0.38) | IGF1RITGALARPOLBL3MBTL1 | |
| SCHEMBL6177034 | 0.85 | IGF1R (0.40) | IGF1RITGALARPOLBL3MBTL1 | |
| SCHEMBL6174845 | 0.85 | NTRK1 (0.38) | ITGALARPOLBL3MBTL1NTRK1 | |
| SCHEMBL6171611 | 0.85 | IGF1R (0.38) | IGF1RITGALARPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |