Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.33 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176324 | 0.86 | IGF1R (0.35) | IGF1RLMNATRPV4 | |
| SCHEMBL6175291 | 0.85 | IGF1R (0.36) | IGF1RLMNA | |
| SCHEMBL6174021 | 0.85 | IGF1R (0.36) | IGF1RLMNA | |
| SCHEMBL6174916 | 0.84 | IGF1R (0.35) | IGF1RPDE2A | |
| SCHEMBL6172540 | 0.83 | IGF1R (0.36) | IGF1RPDE2ALMNA | |
| SCHEMBL6175392 | 0.83 | IGF1R (0.36) | IGF1RLMNA | |
| SCHEMBL6176192 | 0.83 | P2RX3 (0.36) | IGF1RLMNA | |
| SCHEMBL6173968 | 0.83 | IGF1R (0.35) | IGF1RPDE2ALMNA | |
| SCHEMBL6171343 | 0.81 | IGF1R (0.36) | IGF1RPDE2A | |
| SCHEMBL6176997 | 0.79 | KDM4E (0.42) | PDE2ALMNATRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |