Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.57 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | DDX3X | O00571 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11473808 | 0.96 | MGLL (0.55) | MGLLPBRM1NPC1MITFLMNA | |
| SCHEMBL5210688 | 0.90 | MEN1 (0.53) | MGLLPBRM1NPC1MITFLMNA | |
| SCHEMBL8953828 | 0.88 | MGLL (0.51) | MGLLPBRM1NPC1MITFLMNA | |
| Hydrochloric Acid SCHEMBL5216120 | 0.88 | MEN1 (0.55) | MGLLPBRM1NPC1MITFLMNA | |
| SCHEMBL14067799 | 0.86 | NPSR1 (0.49) | MGLLNPC1NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4223030 | 0.85 | MGLL (0.59) | MGLLPBRM1NPSR1CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL5212124 | 0.84 | MGLL (0.57) | MGLLNPSR1CHRNB2CHRNA4 | |
| SCHEMBL5242511 | 0.83 | MGLL (0.47) | MGLLPBRM1NPC1MITFLMNA | |
| SCHEMBL8849948 | 0.81 | PBRM1 (0.46) | MGLLPBRM1NPC1MITFLMNA | |
| SCHEMBL12202677 | 0.79 | SMN1; SMN2 (0.44) | MGLLNPC1SMN1; SMN2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834236-B1 | HETEROCYCLYL COMPOUNDS | LUPIN LTD (IN) | 2019-05-22 | — | — | EP | disclosed |
| EP-2834236-B1 | HETEROCYCLYL COMPOUNDS | LUPIN LTD (IN) | 2019-05-22 | — | — | EP | disclosed |
| US-9827247-B2 | Heterocyclyl compounds | LUPIN LIMITED (IN) | 2017-11-28 | — | — | US | disclosed |
| US-9827247-B2 | Heterocyclyl compounds | LUPIN LIMITED (IN) | 2017-11-28 | — | — | US | disclosed |
| US-9827247-B2 | Heterocyclyl compounds | LUPIN LIMITED (IN) | 2017-11-28 | — | — | US | disclosed |
| US-20170112840-A1 | HETEROCYCLYL COMPOUNDS | LUPIN LIMITED (IN) | 2017-04-27 | — | — | US | disclosed |
| US-20170112840-A1 | HETEROCYCLYL COMPOUNDS | LUPIN LIMITED (IN) | 2017-04-27 | — | — | US | disclosed |
| US-20170112840-A1 | HETEROCYCLYL COMPOUNDS | LUPIN LIMITED (IN) | 2017-04-27 | — | — | US | disclosed |
| US-9573944-B2 | Heterocyclyl compounds | LUPIN LIMITED (IN) | 2017-02-21 | — | — | US | disclosed |
| US-9573944-B2 | Heterocyclyl compounds | LUPIN LIMITED (IN) | 2017-02-21 | — | — | US | disclosed |
| US-5852195-A | Pyranone compounds useful to treat retroviral infections | PHARMACIA & UPJOHN COMPANY (US) | 1998-12-22 | — | — | US | disclosed |
| US-5686486-A | 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl b!pyran-2-ones useful to treat retroviral infections | PHARMACIA & UPJOHN COMPANY (US) | 1997-11-11 | — | — | US | disclosed |
| CN-1150424-A | Compounds for the treatment of retroviral infections | UPJOHN CO (US) | 1997-05-21 | — | — | CN | disclosed |
| EP-0758327-A1 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1997-02-19 | — | — | EP | disclosed |
| CN-1117291-A | 4-Hydroxy-pyran-2-one derivatives for the treatment of retroviral infections | UPJOHN CO (US) | 1996-02-21 | — | — | CN | disclosed |
| EP-0682663-A1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1995030670-A2 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-16 | — | — | WO | disclosed |
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | disclosed |
| WO-1994018188-A1 | 4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL[B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS | THE UPJOHN COMPANY (US) | 1994-08-18 | — | — | WO | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112840-A1 | HETEROCYCLYL COMPOUNDS | NRAS, MAP3K11, MAP3K1 | MGLL 4327/4885PBRM1 629/4885NPC1 1640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.