Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172198 | 0.88 | EPHX2 (0.43) | IGF1RABL1EPHX2 | |
| SCHEMBL6172261 | 0.86 | IGF1R (0.49) | IGF1RSCN9AABL1CYP2C9CYP3A4 | |
| SCHEMBL6177034 | 0.83 | IGF1R (0.40) | IGF1RCYP2C9CYP3A4GAACYP2C19 | |
| SCHEMBL2942458 | 0.83 | IGF1R (0.57) | IGF1R | |
| SCHEMBL6175174 | 0.83 | ABL1 (0.47) | IGF1RABL1RAF1EPHX2 | |
| SCHEMBL6175674 | 0.82 | EPHX2 (0.42) | IGF1RSCN9AEPHX2 | |
| SCHEMBL6176618 | 0.81 | SCN2A (0.38) | SCN2ASCN10AABL1KCNH2GPR139 | |
| SCHEMBL6172594 | 0.81 | AR (0.40) | IGF1RABL1CYP2C9CYP3A4GAA | |
| SCHEMBL6173342 | 0.81 | ABL1 (0.40) | IGF1RABL1ALKROS1EPHX2 | |
| SCHEMBL6171575 | 0.80 | IGF1R (0.40) | IGF1RSCN9ACYP2C9CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |