Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172261 | 0.89 | IGF1R (0.49) | ABL1EPHX2RAF1KDRFLT1 | |
| SCHEMBL6177034 | 0.88 | IGF1R (0.40) | L3MBTL1IGF1RPTGS2 | |
| SCHEMBL6173728 | 0.88 | MEN1 (0.47) | NPC1RAB9AMEN1KMT2AEPHX2 | |
| SCHEMBL6173853 | 0.87 | IGF1R (0.37) | L3MBTL1KMT2AEPHX2IGF1RPTGS2 | |
| SCHEMBL6174831 | 0.86 | IGF1R (0.41) | KMT2ANAMPTGRM1IGF1R | |
| SCHEMBL6172594 | 0.84 | AR (0.40) | ABL1L3MBTL1MEN1KMT2AEPHX2 | |
| SCHEMBL6175032 | 0.83 | MAPK1 (0.43) | MEN1KMT2AEPHX2NAMPTIGF1R | |
| SCHEMBL6171765 | 0.83 | IGF1R (0.41) | MEN1KMT2AEPHX2KDRFLT1 | |
| SCHEMBL6171575 | 0.83 | IGF1R (0.40) | L3MBTL1IGF1RPTGS2 | |
| SCHEMBL6173499 | 0.83 | IGF1R (0.38) | ABL1EPHX2RAF1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |