Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175201 | 0.87 | MAPK7 (0.39) | SCN9APDE2AMAPK7TRPV4KDM4E | |
| SCHEMBL3729343 | 0.87 | MAPK7 (0.42) | MAPK7MAPTPOLBL3MBTL1ROS1 | |
| SCHEMBL6173598 | 0.87 | IGF1R (0.39) | PDE2A | |
| SCHEMBL6174121 | 0.86 | TRPV1 (0.40) | PDE2AMAPK7TRPV4KDM4EMAPT | |
| SCHEMBL6172636 | 0.85 | KDM4E (0.35) | PDE2AMAPK7KDM4EMAPTCSF1R | |
| SCHEMBL6175751 | 0.84 | AR (0.41) | POLBL3MBTL1 | |
| SCHEMBL6173665 | 0.84 | MAPT (0.36) | CCR6SCN9APDE2ATRPV4KDM4E | |
| SCHEMBL6174465 | 0.82 | MAPK7 (0.39) | SCN9APDE2AMAPK7ENPP2MCHR1 | |
| SCHEMBL6177961 | 0.82 | MAPK7 (0.39) | MAPK7KDM4EPOLBL3MBTL1 | |
| SCHEMBL6172700 | 0.81 | TRPV1 (0.46) | TRPV4ENPP2POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |