Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.34 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.34 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASR | P41180 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172470 | 0.87 | IGF1R (0.36) | MAPTALDH1A1MAPK1KDM4EL3MBTL1 | |
| SCHEMBL6174388 | 0.86 | MAPK7 (0.39) | ALDH1A1L3MBTL1TRPV4GAACASR | |
| SCHEMBL6175936 | 0.85 | GPR139 (0.40) | ALDH1A1L3MBTL1GAASCN9APOLB | |
| SCHEMBL6175295 | 0.85 | POLB (0.35) | MAPTALDH1A1L3MBTL1TRPV4GAA | |
| SCHEMBL6173635 | 0.84 | CCR6 (0.35) | MAPTKDM4EL3MBTL1TRPV4PDE2A | |
| SCHEMBL6173272 | 0.83 | GPR139 (0.34) | ALDH1A1L3MBTL1TRPV4GAACASR | |
| SCHEMBL6173352 | 0.83 | CYP3A4 (0.35) | MAPTALDH1A1KDM4EL3MBTL1GAA | |
| SCHEMBL6175751 | 0.81 | AR (0.41) | ALDH1A1L3MBTL1SMN1; SMN2GAAHTT | |
| SCHEMBL6172558 | 0.81 | TRPV4 (0.35) | MAPTALDH1A1MAPK1KDM4EL3MBTL1 | |
| SCHEMBL6172559 | 0.81 | LMNA (0.37) | MAPTALDH1A1MAPK1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |