Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.50 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171654 | 0.87 | TP53 (0.64) | TP53MAPTALDH1A1HPGDTSHR | |
| SCHEMBL7971960 | 0.85 | TP53 (0.64) | TP53MAPTALDH1A1HPGDTSHR | |
| SCHEMBL20767921 | 0.80 | NPC1 (0.48) | TP53MAPTLMNA | |
| SCHEMBL6173220 | 0.77 | TP53 (0.54) | TP53MAPTALDH1A1HPGDTSHR | |
| SCHEMBL6172641 | 0.76 | TP53 (0.61) | TP53MAPTALDH1A1HPGDTSHR | |
| SCHEMBL20795032 | 0.76 | TP53 (0.49) | TP53MAPTLMNASMPD3SUV39H2 | |
| SCHEMBL17310233 | 0.74 | MAP4K4 (0.54) | MAPTALDH1A1LMNASMPD3SUV39H2 | |
| SCHEMBL17310150 | 0.74 | TLR9 (0.51) | MAPTALDH1A1LMNASMPD3SUV39H2 | |
| SCHEMBL31652004 | 0.74 | TLR9 (0.51) | MAPTALDH1A1LMNASMPD3SUV39H2 | |
| SCHEMBL21326439 | 0.73 | TP53 (0.49) | TP53MAPTALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263757-B1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2005-07-27 | — | — | EP | disclosed |
| EP-1263757-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-11 | — | — | EP | disclosed |
| US-6313116-B1 | PHOSPHODIESTERASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2001-11-06 | — | — | US | disclosed |
| WO-2001058897-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |