Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.50 |
| ▸ | CNR2 | P34972 | 5/20 | 0.50 |
| ▸ | ELANE | P08246 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199296 | 0.93 | HTR2B (0.56) | HTR2BMAPTHTR2C | |
| SCHEMBL6174221 | 0.92 | HTR2B (0.49) | CNR1CNR2ELANEHTR2BMAPT | |
| SCHEMBL6178657 | 0.92 | HTR2B (0.57) | HTR2BMAPTHTR2C | |
| SCHEMBL6177760 | 0.88 | HTR2B (0.52) | HTR2BMAPTHTR2C | |
| SCHEMBL2819257 | 0.86 | ELANE (0.63) | ELANEMAPT | |
| Pseudopyronines B SCHEMBL17867169 | 0.86 | ELANE (0.63) | ELANEMAPT | |
| SCHEMBL8780178 | 0.86 | ELANE (0.63) | ELANEMAPT | |
| SCHEMBL6176274 | 0.84 | IDH1 (0.49) | CNR1CNR2HTR2BMAPTHTR2C | |
| SCHEMBL9196012 | 0.81 | HTR2B (0.46) | HTR2BHTR2C | |
| SCHEMBL9199124 | 0.81 | IGF1R (0.46) | HTR2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203770-B1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | UPJOHN CO (US) | 2005-03-09 | — | — | EP | disclosed |
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | disclosed |