SCHEMBL6173952

SCHEMBL6173952

CCOC(c1ccncc1N1CCCC1)N1CC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IGF1R P08069 14/20 0.37
PDE2A O00408 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6175001 0.86 LMNA (0.40) IGF1R
SCHEMBL6174879 0.80 IGF1R (0.40) IGF1RPDE2A
SCHEMBL2938307 0.74 IGF1R (0.41) IGF1R
SCHEMBL2933538 0.74 IGF1R (0.39) IGF1R
SCHEMBL6173968 0.71 IGF1R (0.35) IGF1RPDE2A
SCHEMBL2937915 0.70 IGF1R (0.43) IGF1R
SCHEMBL2935167 0.69 IGF1R (0.43) IGF1R
SCHEMBL2940733 0.68 IGF1R (0.39) IGF1R
SCHEMBL2940328 0.67 IGF1R (0.42) IGF1R
SCHEMBL2941208 0.67 IGF1R (0.64) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 WO disclosed