Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 2/20 | 0.34 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.34 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.34 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.34 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.34 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171026 | 0.86 | AR (0.35) | ARIGF1RPOLBL3MBTL1ITGAL | |
| SCHEMBL6174017 | 0.86 | IGF1R (0.43) | ARIGF1R | |
| SCHEMBL6173567 | 0.85 | IGF1R (0.51) | ARIGF1RITGALHTT | |
| SCHEMBL6173695 | 0.81 | ITGAL (0.40) | ARPOLBL3MBTL1ITGALLIPE | |
| SCHEMBL2938890 | 0.80 | IGF1R (0.54) | IGF1RNTRK1 | |
| SCHEMBL6172285 | 0.79 | MAPK7 (0.39) | ARIGF1RPOLBL3MBTL1TEAD1 | |
| SCHEMBL6174950 | 0.79 | POLB (0.35) | ARIGF1RPOLBL3MBTL1TEAD1 | |
| SCHEMBL6171211 | 0.79 | HCRTR1 (0.39) | POLBL3MBTL1 | |
| SCHEMBL6177887 | 0.79 | PIK3CG (0.37) | ARPOLBL3MBTL1LIPEHSD17B13 | |
| SCHEMBL6175888 | 0.77 | GRM5 (0.35) | ARIGF1RPOLBL3MBTL1TEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |