Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 4/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.34 |
| ▸ | ELOVL3 | Q9HB03 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.33 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.33 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.33 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171026 | 0.90 | AR (0.35) | POLBL3MBTL1ARIGF1RTRPV4 | |
| SCHEMBL6171211 | 0.90 | HCRTR1 (0.39) | POLBL3MBTL1KCNH2SCN5ASCN9A | |
| SCHEMBL6174950 | 0.90 | POLB (0.35) | POLBL3MBTL1ARIGF1RELOVL6 | |
| SCHEMBL6171367 | 0.89 | TEAD1 (0.34) | POLBL3MBTL1ARIGF1RKCNH2 | |
| SCHEMBL6175888 | 0.89 | GRM5 (0.35) | POLBL3MBTL1ARIGF1RELOVL6 | |
| SCHEMBL6172558 | 0.86 | TRPV4 (0.35) | POLBL3MBTL1ELOVL6ELOVL3SCN9A | |
| SCHEMBL6175236 | 0.85 | IGF1R (0.50) | ARIGF1RHTR1AADRA1DADRA1A | |
| SCHEMBL2936644 | 0.80 | IGF1R (0.55) | IGF1R | |
| SCHEMBL6173958 | 0.79 | AR (0.35) | POLBL3MBTL1ARIGF1RTRPV4 | |
| SCHEMBL6174388 | 0.78 | MAPK7 (0.39) | MAPK7POLBL3MBTL1ARELOVL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |