Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.38 |
| ▸ | ECE1 | P42892 | 8/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175582 | 0.85 | MAPT (0.42) | PPARGPTGDR2RAB9AKDM4EGAA | |
| SCHEMBL6019336 | 0.82 | ECE1 (0.52) | PTGDR2ECE1 | |
| SCHEMBL6177715 | 0.74 | ECE1 (0.43) | ECE1FAAHRAB9AKDM4E | |
| SCHEMBL6175264 | 0.71 | ECE1 (0.46) | ECE1RAB9AKDM4EGAAMAPT | |
| SCHEMBL6175232 | 0.70 | ECE1 (0.47) | ECE1MAPT | |
| SCHEMBL6175488 | 0.70 | ECE1 (0.73) | ECE1 | |
| SCHEMBL6172299 | 0.69 | PPARG (0.43) | PPARGPTGDR2TBXA2RMAPT | |
| SCHEMBL6173849 | 0.69 | KMT2A (0.43) | ECE1KDM4E | |
| SCHEMBL6176732 | 0.69 | ECE1 (0.56) | ECE1 | |
| SCHEMBL6019416 | 0.68 | ECE1 (0.63) | ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432415-B1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2005-12-28 | — | — | EP | disclosed |