Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172182 | 0.88 | LMNA (0.44) | IGF1RCYP2C9ALDH1A1GAAITGAL | |
| SCHEMBL6175130 | 0.87 | GRM5 (0.43) | IGF1RCYP2C9POLBTP53ALDH1A1 | |
| SCHEMBL6175931 | 0.87 | IGF1R (0.53) | IGF1R | |
| SCHEMBL6177003 | 0.87 | TDP1 (0.42) | IGF1RKDM4EGAAKITBRAF | |
| SCHEMBL6174108 | 0.85 | NPC1 (0.39) | IGF1RCYP2C9TP53ALDH1A1GAA | |
| SCHEMBL6176511 | 0.85 | NAMPT (0.43) | IGF1RKITBRAF | |
| SCHEMBL6173886 | 0.84 | IGF1R (0.40) | IGF1RCYP2C9ALDH1A1GAA | |
| SCHEMBL6176335 | 0.83 | CYP3A4 (0.46) | IGF1RCYP2C9TP53ALDH1A1KDM4E | |
| SCHEMBL2935996 | 0.83 | IGF1R (0.58) | IGF1R | |
| SCHEMBL6174213 | 0.83 | IGF1R (0.40) | IGF1RCYP2C9ALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |