Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | C5 | P01031 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | MAP2 | P11137 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172407 | 0.92 | PTGS2 (0.46) | PTGS2MAPTMEN1KMT2AABCC4 | |
| SCHEMBL6170491 | 0.80 | PTGS2 (0.49) | PTGS2MAPTMEN1KMT2APTGS1 | |
| SCHEMBL6172346 | 0.79 | MAPT (0.48) | PTGS2MAPTMEN1KMT2AABCC4 | |
| SCHEMBL6171369 | 0.78 | PTGS2 (0.47) | PTGS2MAPTMEN1KMT2AABCC4 | |
| SCHEMBL8126288 | 0.77 | MAPT (0.46) | MAPTPOLBLMNAGAASIRT1 | |
| SCHEMBL6171197 | 0.77 | PTGS2 (0.49) | PTGS2MAPTMEN1KMT2AABCC4 | |
| SCHEMBL6171377 | 0.77 | PTGS2 (0.49) | PTGS2MAPTMEN1KMT2AABCC4 | |
| SCHEMBL6173187 | 0.77 | PTGS2 (0.51) | PTGS2MAPTMEN1KMT2AABCC4 | |
| SCHEMBL6173791 | 0.77 | PTGS2 (0.51) | PTGS2MAPTMEN1KMT2AABCC4 | |
| SCHEMBL6170818 | 0.77 | PTGS2 (0.48) | PTGS2MAPTMEN1KMT2AABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |