Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173238 | 0.90 | IGF1R (0.41) | IGF1RNAMPTALDH1A1TP53KDM4E | |
| SCHEMBL6174555 | 0.88 | IGF1R (0.40) | IGF1RNAMPTALDH1A1TP53PTGS1 | |
| SCHEMBL6172038 | 0.88 | IGF1R (0.41) | IGF1RELANE | |
| SCHEMBL6173098 | 0.88 | FLT1 (0.36) | NAMPTALDH1A1TP53KDM4ELMNA | |
| SCHEMBL6171908 | 0.87 | NAMPT (0.49) | IGF1RNAMPTCYP2C9 | |
| SCHEMBL6174113 | 0.86 | IGF1R (0.40) | IGF1RNAMPTALDH1A1TP53LMNA | |
| SCHEMBL6176685 | 0.84 | IGF1R (0.39) | IGF1RNAMPTALDH1A1TP53PTGS1 | |
| SCHEMBL6174225 | 0.83 | MAPT (0.42) | IGF1RALDH1A1TP53LMNAPTGS1 | |
| SCHEMBL6175985 | 0.83 | IGF1R (0.41) | IGF1RNAMPTALDH1A1TP53KMT2A | |
| SCHEMBL2941469 | 0.82 | IGF1R (0.60) | IGF1RNAMPTAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |