Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168399 | 0.91 | — | — | |
| SCHEMBL7748218 | 0.88 | KDM4E (0.60) | KDM4EL3MBTL1RAD52POLBPKM | |
| Hydrochloric Acid SCHEMBL27400789 | 0.88 | KDM4E (0.60) | KDM4EL3MBTL1POLBPKMTSHR | |
| Bromide SCHEMBL5245144 | 0.88 | KDM4E (0.60) | KDM4EL3MBTL1POLBPKMTSHR | |
| SCHEMBL63826 | 0.88 | KDM4E (0.60) | KDM4EL3MBTL1POLBPKMTSHR | |
| SCHEMBL23014621 | 0.88 | KDM4E (0.60) | KDM4EL3MBTL1RAD52POLBPKM | |
| SCHEMBL1031783 | 0.88 | KDM4E (0.60) | KDM4EL3MBTL1POLBPKMTSHR | |
| Hydrochloric Acid SCHEMBL73679 | 0.88 | KDM4E (0.60) | KDM4EL3MBTL1POLBPKMTSHR | |
| Hydrochloric Acid SCHEMBL2673610 | 0.86 | KDM4E (0.58) | KDM4EL3MBTL1POLBPKMTSHR | |
| Hydrochloric Acid SCHEMBL7527100 | 0.86 | KDM4E (0.58) | KDM4EL3MBTL1POLBPKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-A4 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1465631-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI Pharmaceuticals, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003053366-A2 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARMACEUTICALS, INC. (US) | 2003-07-03 | — | — | WO | disclosed |