Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172547 | 0.89 | IGF1R (0.41) | IGF1RLMNATRPV3JAK2JAK1 | |
| SCHEMBL6250336 | 0.85 | IGF1R (0.43) | IGF1RLMNAJAK2JAK1HRH4 | |
| SCHEMBL6173787 | 0.83 | IGF1R (0.42) | IGF1RLMNAKDM4EALDH1A1NPSR1 | |
| SCHEMBL6173280 | 0.83 | IGF1R (0.42) | IGF1RLMNAJAK2JAK1HRH4 | |
| SCHEMBL6172371 | 0.83 | IGF1R (0.45) | IGF1RLMNATRPV3HTT | |
| SCHEMBL6175238 | 0.83 | IGF1R (0.43) | IGF1RLMNATRPV3ALDH1A1HTT | |
| SCHEMBL6175175 | 0.80 | IGF1R (0.36) | IGF1REPHX2LMNAHTTPTGS2 | |
| SCHEMBL6173570 | 0.80 | IGF1R (0.43) | IGF1RLMNATRPV3 | |
| SCHEMBL6172919 | 0.80 | IGF1R (0.43) | IGF1RLMNATRPV3HRH4 | |
| SCHEMBL6173471 | 0.80 | IGF1R (0.42) | IGF1RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |