Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171408 | 0.90 | IGF1R (0.35) | IGF1RLMNAPTGS2MAPK1HTT | |
| SCHEMBL6175260 | 0.89 | IGF1R (0.39) | IGF1RLMNAPTGS2MAPK1HTT | |
| SCHEMBL6173330 | 0.88 | IGF1R (0.40) | IGF1RLMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL6176021 | 0.88 | IGF1R (0.34) | IGF1RLMNAPTGS2MAPK1HTT | |
| SCHEMBL6174640 | 0.87 | IGF1R (0.37) | IGF1RLMNAPTGS2MAPK1HTT | |
| SCHEMBL6175297 | 0.87 | LMNA (0.39) | IGF1RLMNAPTGS2MAPK1HTT | |
| SCHEMBL6170251 | 0.86 | IGF1R (0.33) | IGF1RLMNA | |
| SCHEMBL6175529 | 0.86 | IGF1R (0.37) | IGF1RLMNA | |
| SCHEMBL6174116 | 0.86 | IGF1R (0.33) | IGF1RLMNAPTGS2 | |
| SCHEMBL6172336 | 0.86 | CACNA1B (0.34) | IGF1RLMNAPTGS2CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | claimed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | claimed |
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |