Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 18/20 | 0.54 |
| ▸ | EGFR | P00533 | 9/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.54 |
| ▸ | FECH | P22830 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.52 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174169 | 0.97 | ERBB2 (0.55) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL6174754 | 0.86 | ERBB2 (0.54) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL5078469 | 0.85 | ERBB2 (0.60) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL6174439 | 0.84 | ERBB2 (0.55) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL4619310 | 0.84 | ERBB2 (0.58) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL215055 | 0.84 | ERBB2 (0.58) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL6173604 | 0.83 | ERBB2 (0.57) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL4616817 | 0.83 | ERBB2 (0.58) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL6176558 | 0.83 | ERBB2 (0.61) | ERBB2EGFRERBB3ERBB4FECH | |
| SCHEMBL4798757 | 0.83 | ERBB2 (0.55) | ERBB2EGFRERBB3ERBB4FECH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292591-B1 | SUBSTITUTED BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PROD INC (US) | 2005-02-02 | — | — | EP | disclosed |